Structural Modifications and Novel Protein-Binding Sites in Pre-miR-675—Explaining Its Regulatory Mechanism in Carcinogenesis

Pre-miR-675 is a microRNA expressed from the exon 1 of H19 long noncoding RNA, and atypical expression pre-miR-675 has been linked with several diseases disorders including cancer. To execute its function inside cell, folded into particular conformation, which aids in interaction other biological molecules. However, exact folding dynamics protein-binding motifs are currently unknown. Moreover, how lncRNA crosstalk modulate each other’s activities also unclear. The detailed structural analysis this study determines earlier unknown conformation identifies novel sites on pre-miR-675, thus making it an excellent therapeutic target against Co-folding between determine transformations describing mechanism these two Comprehensively, details explains relationship lncRNA, can be interpreted to understand role development progression tumorigenesis designing new therapeutics cancers.